教育背景

2000-2007    哈尔滨医科大学       基础 医 学       本科、硕士

2007-2012    香港大学我院        内   科   系        博    士

工作经历

主要研究领域

心脏是机械敏感性器官，机械牵拉能引起心肌结构和功能性改变，是诱发心脏功能衰竭主要刺激因素。虽然心脏能够动态地适应机械负荷，适应不良刺激和慢性超负荷，这两者的结果对心脏功能产生不利影响。机械应力诱导心脏肾素 - 血管紧张素系统，导致局部血管紧张素II产生增加并刺激心肌重塑引起心肌肥厚。此外，在心脏细胞，肿胀发生在糖尿病患者或感染性休克和心跳骤停，以及心肌缺血/再灌注。机械应力的改变以及肿胀导致结构和离子通道和电生理重构，有收缩功能障碍，细胞死亡，和心律失常增强倾向。

张雁惠教授主要从事离子通道与冠心病、心肌缺血再灌注损伤、心肌肥厚、心衰、心率失常等心脏疾患的发病机理的研究，为心血管疾病的治疗寻找新的干预措施和新的治疗药物。目前的主要研究方向为：1）将肿胀/牵拉相关蛋白SWELL1的研究范围扩展到心脏组织/细胞。在心肌缺血再灌注模型研究SWELL1功能对急性或慢性心脏障碍的影响；2）SWELL1在糖尿病心脏病中的作用；3）TRP通道在心脏疾患病理进程中的作用以及干预。近年来在国际著名杂志 Nature Cell Biology、Cardiovascular Research、British Journal of Pharmacology发表论文14篇；主持美国AHA青年科研基金1项。

主要论著

• Zhang Y, Xie L, Gunasekar S, Tong D, Mishra A, Gibson W, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel D, Smith J, Samuel I, Cao L, Sah R. SWELL1 is a regulator of adiocyte size, insulin signaling and glucose homeostasis. Nature Cell Biology.2017 May;19(5):504-517  [Abstract]  IF=20.059 

• Chen Kang, Litao Xie, Susheel Gunasekar, Anil Mishra, Yanhui Zhang, Saachi Pai, Yiwen Gao, Ashutosh Kumar, Andrew Norris, Samuel Stephens, and Rajan Sah.SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia. Nat Commun.2017 Dec. in press  IF=12.124

• Xie L,Zhang Y, Gunasekar SK, Mishra A, Cao L, Sah R. Induction of adipose and hepatic SWELL1 expression is required for maintaining systemic insulin-sensitivity in obesity. Channels (Austin). 2017 Sep 5:1-5  [Abstract] 

• Zhang Y, Tong D, Mishra A, Xie L, Sah R. Isolation and patch-clamp of primary adipocytes. Thermogenic Fat: Methods and Protocols  Springer New York: 145-150. 2017.[Abstract] 

• Wang R, Lu Y, Gunasekar S, Zhang Y, Benson CJ, Chapleau M, Sah R, Abboud FM.  The Volume-Regulated Anion Channel (LRRC8) in Nodose Neurons is Sensitive to Acid pH.JCI Insight.2017; 2(5):e90632. [Abstract]
  

• Xiao GS, Zhang YH,Wu W, Sun HY, Wang Y, Li GR. Genistein and tyrphostin AG556 decrease ultra-rapidly activating delayed rectifier K+ current of human atria by inhibiting EGF receptor tyrosine kinase.Br J Pharmacol.2017; 174(6):454-467.  [Abstract] IF=5.228                                     

• Zhang YH, Wu HJ, Che H, Sun HY, Cheng LC, Li X, Au WK, Tse HF, Li GR. Functional transient receptor potential canonical type 1 channels in human atrial myocytes.Pflugers Arch. 2013; 465(10):1439-49.  [Abstract]  IF=4.866 

• Wu HJ, Sun HY, Wu W, Zhang YH, Qin GW, Li GR. Properties and molecular determinants of the natural flavone acacetin for blocking hKv4.3 channels.PloS One.2013; 8(3):e57864.  [Abstract] IF=3.73
  
  

• Qin X, Yue Z, Sun B, Yang W, Xie J, Ni E, Feng Y, Mahmood R, Zhang Y, Yue L.Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels.  Br J Pharmacol.2013; 168(6):1294-312.  [Abstract] IF=5.067
  
  

• Yue Z, Zhang Y, Xie J, Jiang J, Yue L. Transient receptor potential (TRP) channels and cardiac fibrosis. Curr Top Med Chem2013; 13(3):270-82.  [Abstract]  IF=3.7
  
  

• Zhang YH, Sun HY, Chen KH, Du XL, Liu B, Cheng LC, Li X, Jin MW, Li GR. Evidence for functional expression of TRPM7 channels in human atrial myocytes. Basic Res Cardiol.2012;107(5):282..   [Abstract]  IF=5.904
  
  

• Xu XH, Sun HY, Zhang YH, Wu W, Chen KH, Liu Y, Deng CY, Yu XY, Jin MW, Li GR. Allitridi inhibits multiple cardiac potassium channels expressed in HEK 293 cells.PloS One.2012; 7(12):e51550.   [Abstract]  IF=4.092
  
  

• Zhang YH, Wu W, Sun HY, Cheng LC, Li X, Tse HF, Lau CP, Li GR. Modulation of human cardiac transient outward potassium current by EGFR tyrosine kinase and Src-family kinases.  Cardiovasc Res.2012; 1;93(3):424-33.   [Abstract] IF=6.064
  
  

• Zhang DY, Zhang YH, Sun HY, Lau CP, Li GR. Epidermal growth factor receptor tyrosine kinase regulates the human inward rectifier potassium channel Kir2.3 stably expressed in HEK 293 cells. Br J Pharmacol. 2011;164(5):1469-78   [Abstract] IF=4.925
  
  

• Zhou Y, Wu HJ, Zhang YH, Sun HY, Wong TM, Li GR, Ionic mechanisms underlying arrhythmogenic effect of the organochloride solvent trichloromethane. Toxicology.2011; 18;290(2-3):295-304. [Abstract] IF=3.641.
  
  

承担课题

• 2016-2017    美国心脏协会（AHA）博士后青年科研基金    《SWELL1, a putative regulator of adipocyte size and obesity》      
  

获奖

• 2016   美国Iowa大学Carver我院内科系 基础科研一等奖